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trastuzumab deruxtecan, pazopanib. Both boosts toxicity of one other by immunosuppressive consequences; danger of infection. Use Warning/Keep track of. Neutropenia or febrile neutropenia incidence have been enhanced when trastuzumab was coadministered with myelosuppressive chemotherapy. .Watch Carefully (1)DHEA, herbal will boost the degree or impact of pazopanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Prevent coadministration of pazopanib with solid CYP3A4 inhibitors if at all possible; if have to coadminister, reduce pazopanib dose to 400 mg/working day
ibuprofen/famotidine will decrease the level or effect of pazopanib by expanding gastric pH. Applies only to oral form of both of those agents.
apalutamide will minimize the level or impact of pazopanib by rising elimination. Use Caution/Keep an eye on. Apalutamide weakly induces BCRP and will minimize systemic exposure of drugs which are BCRP substrates.
Pazopanib could trigger intense or daily life-threatening liver harm. Notify your medical doctor When you have or have ever experienced liver ailment. When you practical experience any of the next indications, phone your health care provider quickly: yellowing of the pores and skin or eyes; darkish urine; Extraordinary tiredness; nausea; vomiting; lack of urge for food; agony inside the upper suitable Component of the stomach; or abnormal bleeding or bruising.
grapefruit will boost the stage or outcome of pazopanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Stay clear of coadministration of pazopanib with strong CYP3A4 PF 477736 inhibitors if at all possible; if must coadminister, minimize pazopanib dose to four hundred mg/day
ribociclib will boost the degree or result of pazopanib by impacting hepatic/intestinal enzyme Salvianolic Acid C CYP3A4 metabolism. Use Caution/Keep track of.
acetazolamide will raise the level or impact of pazopanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unknown.
Istradefylline forty mg/working day increased peak degrees and AUC of CYP3A4 substrates in clinical trials. This outcome was not observed with istradefylline twenty mg/working day. Contemplate dose reduction of delicate CYP3A4 substrates.
Avoid or Use Alternate Drug. Keep away from coadministration of pazopanib with medication that increase gastric pH; may perhaps use quick-performing antacids rather than PPIs and H2 antagonists, but different antacid and pazopanib dosing by numerous hrs
convey to your physician and pharmacist For anyone who is allergic to pazopanib, almost every other prescription drugs, or any with the elements in pazopanib tablets. Check with your pharmacist or Test the Medication Guidebook for a list of the substances.
Stay away from concomitant use of tucatinib with CYP3A substrates, in which minimum concentration modifications could bring about major or life-threatening toxicities. If unavoidable, decrease CYP3A substrate dose In accordance with merchandise labeling.
pazopanib will boost the stage or effect of tazemetostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pazopanib will enhance the degree or impact of Dioscin atogepant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.